The 2025 Nobel Prize in Physiology or Medicine has been awarded to three scientists: Mary E. Brunkow, Fred Ramsdell and Shimon Sakaguchi. Their pioneering work focused on how the immune system avoids attacking the body’s own tissues, an issue central to many diseases. The Nobel Assembly at the Karolinska Institute in Stockholm announced the winners today, bringing lasting recognition to their contributions, according to Euronews.
Brunkow and Ramsdell work in the United States, while Sakaguchi is based in Japan. Together, they revealed mechanisms behind peripheral immune tolerance. This biological process prevents autoimmune reactions that can be harmful. Citing the...